Strategies for Antiviral Drug Discovery

Ethnomedicines in Antiviral Drug Discovery

This review is an attempt to portray the discovery and development of ethnomedicine and its phytophores against some important viral diseases from galenical to genomical period. Natural resource, particularly the plants and animals have been the basis of traditional treatment since the dawn of human civilization and the modern medicine (Allopathy) has gradually developed, over the years, by sci...

Achievements and challenges in antiviral drug discovery.

The last 40 years have seen the development of several antiviral drugs with therapeutic value in treating life-threatening or debilitating diseases such as those caused by HIV, hepatitis B virus, herpesviruses (such as herpes simplex virus and varicella zoster virus) and influenza virus. These relatively recent advances have been due to technical breakthroughs in the cultivation of viruses in t...

Current Landscape of Antiviral Drug Discovery

Continued discovery and development of new antiviral medications are paramount for global human health, particularly as new pathogens emerge and old ones evolve to evade current therapeutic agents. Great success has been achieved in developing effective therapies to suppress human immunodeficiency virus (HIV) and hepatitis B virus (HBV); however, the therapies are not curative and therefore cur...

Targeting Norovirus: Strategies for the Discovery of New Antiviral Drugs

Flexible Text Mining Strategies for Drug Discovery

The two text mining strategies: finding co-occurrences of biological entities within documents, and finding relationships using Natural Language Processing, are often seen as competitors. Here we adopt a flexible approach where the techniques are adapted and combined to suit the nature of the document corpus, and the specific task. The approach was tested on three tasks relevant to cancer treat...